What should be done if a ferret bites during a restraint attempt?

Using running water to break the grip of a ferret that is biting is the best response in this situation because it utilizes a natural instinct of the animal to release its bite. Ferrets, like many other species, may loosen their grip when they encounter an unexpected and gentle stimulus, such as running water. This approach minimizes further stress or injury to both the animal and the person involved, allowing for a safer disengagement.

Placing the ferret in an enclosed area or holding its mouth closed could escalate the situation by increasing the animal's fear or aggression, possibly leading to more bites or injury. Attempting to pull the ferret away quickly risks causing additional harm, either to the person or the animal, as it could result in tearing of the skin or an uncontrollable response from the ferret. Thus, using running water is a safe and effective method to handle the situation without exacerbating it.